[Occupational decisions of young physicians and possible future consequences for the provision of medical care. Results of an anonymous questionnaire]. / Veränderte Berufsentscheidungen junger Arzte und mögliche Konsequenzen für das zukünftige ärztliche Versorgungsangebot. Ergebnisse einer anonymen Befragung.

OBJECTIVE: This study was undertaken following a request of the Bavarian Ministry of Sciences, Research and the Arts to analyse the future provision in different occupational areas. METHODS: In a preliminary enquiry, statistics of the Medical Association of Bavaria (BLAEK) were analysed for several years (2000-2004) to find out how many physicians are working in different occupational areas and fields, according to gender. In early 2004 a questionnaire was sent to all physicians who had received their licences to practise medicine in the four preceding years and were still reported to the Medical Association of Bavaria. At the time of the questioning the participants worked in Bavaria or abroad. RESULTS: The study shows that, with regard to their growing share in the medical workforce and the role they will play in medical care in future, female physicians must be put into the focus of attention. Their decisions as to which career to pursue differ from those of their male colleagues because of their experience during their further training and their need to manage both a family and a job. Another finding is that the participants of the survey are not content with their working conditions. They criticize that they have to spend too much of their working time with documentation and other administrative duties so that there is not enough time left for their patients. Many complain about the heavy responsibility of their jobs and too much work in relation to their remuneration. CONCLUSION: To prevent a future shortage in medical care, the following measures should be taken: creation of family-oriented working conditions in hospitals; support of female physicians in their careers; increase of attractiveness of hospital employment.

[Acute generalized exanthematous pustulosis with confirmed type IV allergy. Report of 3 cases]. / Akute generalisierte exanthematische Pustulose bei nachgewiesener Typ-IV-Allergie: Bericht über 3 Patienten.

Acute generalized exanthematous pustulosis (AGEP) is characterized by an acute disseminated eruption of multiple, non-follicular pustules. In addition, it can be associated with fever, elevated erythrocyte sedimentation rate, and leukocytosis. The pathogenesis of AGEP is still unknown; however, medications appear a likely cause in most cases. We report on 3 patients with AGEP demonstrating characteristic clinical and histologic features after taking amoxicillin, ampicillin, or diltiazem. All patients had positive patch test reactions to the suspected drugs.

[Cutaneous lupus erythematosus. Part 2: diagnostics and therapy]. / Kutaner Lupus erythematodes. Teil 2: Diagnostik und Therapie.

The diagnosis of cutaneous lupus erythematosus (CLE) requires a specific diagnostic approach to identify subtypes, to address differential diagnostic considerations, and to rule out systemic organ involvement. In addition to a detailed patient's history and clinical evaluation of the skin, histopathologic and immunofluorescent examination of a skin biopsy as well as laboratory screening are recommended. Photoprovocation tests can be performed to confirm the diagnosis of CLE and to assess photosensitivity in these patients. Recently, a scoring system for the activity of the cutaneous manifestations in CLE has been developed and validated which involves anatomical areas and morphologic signs of the skin lesions. In all subtypes of CLE, antimalarials are still the treatment of choice. Advances in biotechnology have led to the development of several novel agents for the treatment of autoimmune diseases; however, controlled trials have not been performed in patients with CLE. Furthermore, there is need for specific immunointervention, especially for patients who fail to respond to standard therapies. The second part of this review will enable the reader to differentiate CLE from other diseases and to suggest specific diagnostic procedures and treatment approaches.

[Cutaneous lupus erythematosus. Part 1: clinical manifestations and classification]. / Kutaner Lupus erythematodes. Teil 1: Klinik und Klassifikation.

Cutaneous lupus erythematosus (CLE) is a heterogenous disorder with a wide range of skin manifestations. Therefore, it has been difficult to develop a unifying concept for classifying CLE from the dermatologic perspective in the past. In 2004, the classification system was updated and includes now acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE), and intermittent CLE (ICLE). Additional rarely described variants are not listed as separate entities but are included in the classical forms. Diagnosis of the different subtypes of CLE is made by considering genetic, clinical, histopathologic, and immunoserologic findings, with a systematic analysis of individual criteria. In the past years, the etiology and pathogenesis of CLE has been subject of intensive research and it has been shown by several groups that exogenous factors, such as ultraviolet light and drugs, can induce CLE. The first part of this review will enable the reader to identify the various clinical manifestations of CLE and to employ characteristic criteria to assess differential diagnostic considerations.

[Connective tissue diseases in childhood]. / Kollagenosen im Kindesalter.

Connective tissue diseases are a heterogeneous group of chronic multisystem inflammatory disorders including systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), dermato- (DM) and polymyositis (PM), mixed connective tissue disease (MCTD), and Sjögren's syndrome (SS). Patients can present with similar clinical features, particularly during the first onset of symptoms, which frequently makes the diagnosis of a specific disease difficult. The incidence of connective tissue diseases is much lower in children than adults; however, the clinical picture is more variable. Clinical signs, such as fatigue, fever, or weight loss, may precede any systemic organ involvement and in children, mucocutaneous manifestations develop most frequently during the varying disease course. This review summarizes recent information on epidemiology, clinical manifestations, diagnostic procedures, and treatment strategies of the different connective tissue diseases, concentrating on specific problems in childhood.